Griffith's well-known drug and alcohol addictions stalled her career, but she made a comeback at age 26 with her role as a porn actress in the Brian De Palma thriller Body Double (1984).The film, although a commercial failure, earned her the National Society of Film Critics Award for Best Supporting Actress.It led to her first starring role in Jonathan Demme's Something Wild (1986), which became a cult favorite.Griffith also starred in the science fiction film Cherry 2000, which went straight to video in 1988 but has also become a cult favorite."What I did was drink myself to sleep at night," she said.He is a celebrated sex symbol – one of those men, like Ben Affleck, George Clooney or Brad Pitt, who make women all over the world cry with delight.Untrained in song and dance, she still impressed New York Times theater critic Ben Brantley, who wrote: "Ms.Griffith is a sensational Roxie, possibly the most convincing I have seen" and "[the] vultures who were expecting to see Ms. She played Caan's mother again during 2014–16 in a recurring role on his television show Hawaii Five-0. In the interim, Griffith guest-starred on Nip/Tuck and Hot in Cleveland.
She was cast as "Melanie", the daughter of her real life mother, Tippi Hedren, in the film Roar (1981), directed by then-stepfather Noel Marshall.
Later that year, she starred as a free-spirited heroin user in the independent film Another Day in Paradise (1998), a performance that some critics described as the best of her career.
In 1999, Griffith starred in Crazy in Alabama, a film directed by Banderas and produced by Greenmoon Productions, the company that she and Banderas formed together.
She achieved mainstream success when Mike Nichols cast her as spunky secretary Tess Mc Gill in the box office hit Working Girl (1988), co-starring Harrison Ford, Sigourney Weaver, Alec Baldwin and Joan Cusack.
Griffith's performance was nominated for an Academy Award for Best Actress and won her the Golden Globe Award for Best Actress in a Musical or Comedy.
In the film, Griffith played an eccentric woman who kills her husband and heads to Hollywood to become a movie star.